SUMMARY: The research focuses on the experimental work-out of clinically relevant unsolved problems regarding cardio-circulatory physiology in the field of adult and congenital cardiology, through the use of large animal models. This translational research includes biventricular assessment of myocardial function based on P-V loops technology, electrophysiological testing, interventional cardiac imaging and catheter-based procedures and exploration of specific cardiac surgery applications with/without use of cardiopulmonary bypass.
Regarding congenital heart disease, contribution to the understanding of the right ventricle-pulmonary valve relationship has been studied in animal models mimicking the sequelae of tetralogy of Falot. Other models of interest were aortic coarctation and single lung-pulmonary hypertension. Regarding the area of adult heart diseases, additional study has been performed on ventriculo-arterial coupling in relation to pulmonary hypertension, and assessment of right ventricular adaptation during LVAD application in a sheep model of myocardial infarction.