GATE TECHNOLOGIES

Cells, 3D cultures and organoids

GATE integrates know-how of stem cell engineering with fundamental research of (developmental) biology and biomechanics to find ways to direct cell differentiation into tissue-specific cells, promote cell-matrix interaction and cell-to-cell communication, and to inducing vascularization in 3D tissue constructs, for example.

Tagged members

Prof. Jan Gettemans

Jan Gettemans is full professor at the Department of Biomolecular Medicine, Faculty of Medicine and Health Sciences. His main focus is research on nanobodies (single domain antibodies) and their implementation in a diverse array of (bio)medical settings.

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CELL THERAPY, GENE THERAPY, CELLS, 3D CULTURES AND ORGANOIDS, BIOMATERIALS AND PROCESSING, ANALYTIC TOOLS IN GENE, CELL AND TISSUE ENGINEERING, GENES & NANODELIVERY SYSTEMS
Prof. Tom Van de Wiele

Tom Van de Wiele is a full professor at the Center for Microbial Ecology and Technology from Ghent University. The research emphasis of his team is the study of host-microbe interactions through the development of innovative in vitro enabling technologies that mimic specific microenvironments of the human body. The generated knowledge complements in vivo observations by providing mechanistic data. It also offers the opportunity to conduct mode of action studies and design novel preventive and therapeutic strategies to steer the microbiome in a health promoting direction through diet, pharmaceuticals, nutraceuticals and live biotherapeutic products.

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CELLS, 3D CULTURES AND ORGANOIDS, BIOMATERIALS AND PROCESSING
Prof. Frank Speleman

Frank Speleman is professor at the Department of Biomolecular Medicine, Faculty of Medicine and Health Sciences. His main focus is the study of perturbed gene regulatory processes in paediatric cancer, more specifically neuroblastoma and T-ALL.

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TISSUE ENGINEERING RESEARCH, CELL THERAPY, ORGANOIDS AND ORGANONCHIP, MICROFLUIDICS AND LABONCHIP, BIOMATERIALS AND PROCESSING, ANALYTIC TOOLS IN GENE, CELL AND TISSUE ENGINEERING, GENES & NANODELIVERY SYSTEMS, REGULATORY AND CLINICAL TRIALS, CELLS, 3D CULTURES AND ORGANOIDS
Prof. Nico Callewaert

Nico Callewaert is group leader and director of the VIB-UGent Center for Medical Biotechnology and full professor in biochemistry and biotechnology at Ghent University. His research interests focus on the invention of technologies for medicine, proteins and sugars.

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CELL THERAPY, ANALYTIC TOOLS IN GENE, CELL AND TISSUE ENGINEERING, GENES & NANODELIVERY SYSTEMS, CELLS, 3D CULTURES AND ORGANOIDS, GMP MANUFACTURING
Prof. Olivier De Wever

Olivier De Wever is Full Professor at Ghent University, Faculty of Medicine and Health Sciences. He is co-director of the Laboratory of Experimental Cancer Research. His focus is on 3D cell cultures and tumor environment modeling and interactions in cancer.

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CELLS, 3D CULTURES AND ORGANOIDS
Prof. Kevin Braeckmans

Kevin Braeckmans is Full Professor at Ghent University, faculty of Pharmaceutical Sciences. He is co-director of the Lab. Of General Biochemistry and Physical Pharmacy and group leader of the Biophotonics Research Group. His focus is on light-based technologies for investigating and facilitating drug delivery to cells and tissues, including for cell therapy applications.

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CELL THERAPY, GENE THERAPY, CELLS, 3D CULTURES AND ORGANOIDS, ANALYTIC TOOLS IN GENE, CELL AND TISSUE ENGINEERING, GENES & NANODELIVERY SYSTEMS
Prof. Stan Monstrey

Former Chairman of the Department of Plastic Surgery and Burn Center at the Ghent University Hospital.

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TISSUE ENGINEERING RESEARCH, CELL THERAPY, CELLS, 3D CULTURES AND ORGANOIDS, BIOMATERIALS AND PROCESSING, REGULATORY AND CLINICAL TRIALS
Prof. Richard Hoogenboom

Richard Hoogenboom is full professor at Ghent University and heads the supramolecular chemistry group that focuses on the development of advanced functional materials.

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CELLS, 3D CULTURES AND ORGANOIDS, BIOMATERIALS AND PROCESSING, GENES & NANODELIVERY SYSTEMS
Prof. Jolanda van Hengel

Prof. Jolanda van Hengel is heading the medical cell biology group. Her group focuses on the in vitro engineering of functional myocardium that mimics human heart tissue for analysis of myocardial function. Also her group tries to obtain a suitable stem cell type for in vitro meat production.

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TISSUE ENGINEERING RESEARCH, CELL THERAPY, GENE THERAPY, ORGANOIDS AND ORGANONCHIP, MICROFLUIDICS AND LABONCHIP, CELLS, 3D CULTURES AND ORGANOIDS, BIOMATERIALS AND PROCESSING, ANALYTIC TOOLS IN GENE, CELL AND TISSUE ENGINEERING, GENES & NANODELIVERY SYSTEMS, REGULATORY AND CLINICAL TRIALS, GMP MANUFACTURING
Dr. Aurélie Crabbé

Aurélie Crabbé is an assistant professor at the Laboratory of Pharmaceutical Microbiology at Ghent University. She studies host-microbe interactions in the context of infectious and inflammatory diseases, with focus on chronic lung diseases. To this end, she uses and develops in vivo-like three-dimensional cell culture models that mimic key phenotypic characteristics of the host tissue.

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CELLS, 3D CULTURES AND ORGANOIDS
Prof. Frauke Coppieters

Frauke Coppieters is assistant professor within RARE-MED, a Ghent University multidisciplinary consortium for basic and translational research on precision medicine for rare diseases (Department of Biomolecular Medicine, Faculty of Medicine and Health Sciences). Her research focuses on retinal disease modelling and new genetic therapies for inherited blindness.

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GENE THERAPY, ORGANOIDS AND ORGANONCHIP, CELLS, 3D CULTURES AND ORGANOIDS, ANALYTIC TOOLS IN GENE, CELL AND TISSUE ENGINEERING, GENES & NANODELIVERY SYSTEMS
Prof. Sarah Vergult

Sarah Vergult is an assistant professor at the Department of Biomolecular Medicine, Faculty of Medicine and Health Sciences, Ghent University. She is partner of the Ghent University RARE-MED consortium, that aims to address missing heritability in rare disorders. She studies the role of the noncoding part of the genome in rare diseases, in particular in neurodevelopmental disorders and implements tools to functionally characterize candidate genes for neurodevelopmental disorders.

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GENE THERAPY, ANALYTIC TOOLS IN GENE, CELL AND TISSUE ENGINEERING, CELLS, 3D CULTURES AND ORGANOIDS
Prof. Bert Devriendt

Bert Devriendt is an assistant professor at the laboratory of Immunology, Faculty of Veterinary Medicine. His research focuses on host-pathogen interactions in the gut and the delivery of therapeutics to the gut tissues. His group develops gut organoids to facilitate this research.

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TISSUE ENGINEERING RESEARCH, ORGANOIDS AND ORGANONCHIP, CELLS, 3D CULTURES AND ORGANOIDS
Prof. Ward De Spiegelaere

Ward De Spiegelaere is assistant professor at the Department of Morphology, Faculty of Veterinary Medicine. His main focus is angiogenesis in wound healing, cancer and tissue engineering.

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TISSUE ENGINEERING RESEARCH, ANALYTIC TOOLS IN GENE, CELL AND TISSUE ENGINEERING, CELLS, 3D CULTURES AND ORGANOIDS
Prof. Katrien Remaut

Katrien Remaut is associate professor at the Lab General Biochemistry and Physical Pharmacy and focuses on nanoparticle-based approaches for ocular gene delivery and the treatment of peritoneal carcinomatosis.

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GENE THERAPY, GENES & NANODELIVERY SYSTEMS, CELLS, 3D CULTURES AND ORGANOIDS
Prof. Tom Coenye

Tom Coenye leads the Laboratory of Pharmaceutical Microbiology. His research is centered around microbial biofilm formation, the evaluation of novel strategies to prevent biofilm formation and/or eradicate existing biofilms, and the molecular basis of tolerance and resistance in biofilms.

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ORGANOIDS AND ORGANONCHIP, CELLS, 3D CULTURES AND ORGANOIDS, BIOMATERIALS AND PROCESSING
Prof. Lindsey Devisscher

Lindsey Devisscher is professor and head of the Gut-Liver ImmunoPharmacology (GLIPh) unit at the Department of Basic and Applied Medical Sciences at the Faculty of Medicine and Health Sciences. Her group focusses on the pathogenesis and new therapeutic options for (gastro-intestinal associated) liver diseases, with emphasize on immunity.

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CELLS, 3D CULTURES AND ORGANOIDS
Prof. Hans Van Vlierberghe

Full Professor in Gastroenterology and Hepatology. Head of department of Gastroenterology and Hepatology. Research focus is on hepatocellular carcinoma in liver cirrhosis and transplantation.

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CELLS, 3D CULTURES AND ORGANOIDS
Prof. Ruslan Dmitriev

Ruslan Dmitriev leads the Tissue Engineering and Biomaterials group at the Department of Human Structure and Repair, Ghent University.

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TISSUE ENGINEERING RESEARCH, ORGANOIDS AND ORGANONCHIP, MICROFLUIDICS AND LABONCHIP, CELLS, 3D CULTURES AND ORGANOIDS, BIOMATERIALS AND PROCESSING, GENES & NANODELIVERY SYSTEMS, ANALYTIC TOOLS IN GENE, CELL AND TISSUE ENGINEERING
Dr. Bernard Depypere

Bernard Depypere, MD received his medical degree from the University of Ghent. He started his training to become Plastic & Reconstructive Surgeon in 2013 and is now chair member at the department of Prof. Dr. Blondeel in Ghent.

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STEERING COMMITTEE, CELLS, 3D CULTURES AND ORGANOIDS, TISSUE ENGINEERING RESEARCH, REGULATORY AND CLINICAL TRIALS
Prof. Phillip Blondeel

Phillip Blondeel is full Professor of Plastic Surgery at the Ghent University, Belgium. He is the head of the Department of Plastic and Reconstructive Surgery and at the Burn Center of the Ghent University Hospital.

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STEERING COMMITTEE, TISSUE ENGINEERING RESEARCH, REGULATORY AND CLINICAL TRIALS, CELLS, 3D CULTURES AND ORGANOIDS
Prof. Catharina De Schauwer

Catharina De Schauwer set up a state-of-the-art laboratory focusing on the isolation, characterization, differentiation and cryopreservation of mesenchymal stem cells, isolated from different sources (including bone marrow, adipose tissue, peripheral blood, umbilical cord blood and Wharton’s jelly) and in different species (including horse, dog and cow).

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CELLS, 3D CULTURES AND ORGANOIDS, TISSUE ENGINEERING RESEARCH