Member info

• FACULTY:
  Faculty of Sciences
• DEPARTMENT:
  Department of Organic and Macromolecular Chemistry
• RESEARCH GROUP:
  Organic and Biomimetic Chemistry Research group (OBCR)
• FUNCTION:
  Full Professor, PI
• WORK ADDRESS:
  Krijgslaan 281 building S4, 9000 Gent, Belgium
• PUBLICATIONS:
  ORCID
• SUMMARY:
  OBCR is specialized in the design and synthesis of modified peptides and nucleic acids and methods for their conjugation and labeling. More specifically, major research interests include: – The construction of conformationally defined peptide architectures. Scaffold decoration, cyclisation and peptide stapling are used to impose a particular conformation and stability on the parent peptides. The synthesized compounds can find applications as peptide vaccins, peptide hydrogels, protein mimetics, DNA-binding ligands and artificial receptors or synthetic antibodies. – The use of our versatile proprietary hydrogel systems as scaffold for controlled drug delivery. – The development of new methods for crosslinking and labeling of biomacromolecules such as peptides, proteins and oligonucleotides. E.g. a very efficient furan-oxidation based method has been developed for the site-selective labeling or introduction of covalent bonds between two binding partners. – The design of novel reactive peptide and oligonucleotide based probes, including peptide nucleic acids, for applications in antisense and antigene strategies, protein and miRNA/lncRNA target identification and receptor pulldown.
• EMAIL:
  Annemieke.madder@ugent.be
• WEBLINK:
  https://www.ugent.be/we/orgchem/en/research