Member info

  • FACULTY:
    Faculty of Sciences
  • DEPARTMENT:
    Department of Organic and Macromolecular Chemistry
  • RESEARCH GROUP:
    Organic and Biomimetic Chemistry Research group (OBCR)
  • FUNCTION:
    Full Professor, PI
  • WORK ADDRESS:
    Krijgslaan 281 building S4, 9000 Gent, Belgium
  • SUMMARY:
    OBCR is specialized in the design and synthesis of modified peptides and nucleic acids and methods for their conjugation and labeling. More specifically, major research interests include: – The construction of conformationally defined peptide architectures. Scaffold decoration, cyclisation and peptide stapling are used to impose a particular conformation and stability on the parent peptides. The synthesized compounds can find applications as peptide vaccins, peptide hydrogels, protein mimetics, DNA-binding ligands and artificial receptors or synthetic antibodies. – The use of our versatile proprietary hydrogel systems as scaffold for controlled drug delivery. – The development of new methods for crosslinking and labeling of biomacromolecules such as peptides, proteins and oligonucleotides. E.g. a very efficient furan-oxidation based method has been developed for the site-selective labeling or introduction of covalent bonds between two binding partners. – The design of novel reactive peptide and oligonucleotide based probes, including peptide nucleic acids, for applications in antisense and antigene strategies, protein and miRNA/lncRNA target identification and receptor pulldown.

Prof. Dr. Annemieke Madder is heading the Organic and Biomimetic Chemistry Research Group specialized in the design and synthesis of modified peptides and nucleic acids and methods for their conjugation and labeling.

More in this category:
Design Escapes

BROCHURES

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